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Lubistone 24mcg Soft Gelatin Capsule 1 Strip
Lubistone is used for the treatment of the following conditions:
- Chronic Idiopathic Constipation (CIC): Recommended for adults experiencing long-term constipation with no identifiable cause.
- Opioid-induced constipation (OIC): Prescribed for adults suffering from constipation due to opioid medications.
- Irritable Bowel Syndrome with Constipation (IBS-C): The only FDA-approved medication for treating IBS-C in women aged 18 years and older.
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✅ Description:
Lubiprostone is a chloride channel activator that increases intestinal fluid secretion, promoting bowel movements without affecting sodium and potassium levels in the blood. It activates ClC-2 channels on the intestinal lining, improving stool passage and relieving constipation symptoms.
Additionally, Lubiprostone restores the intestinal mucosal barrier by enhancing tight junction proteins. It acts locally in the intestines; symptom relief is usually observed within 24 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration
- Chronic Idiopathic Constipation (CIC): 24 mcg twice daily with food and water.
- Opioid-induced constipation (OIC): 24 mcg twice daily with food and water.
- Irritable Bowel Syndrome with Constipation (IBS-C): 8 mcg twice daily with food and water.
- Children & Adolescents: Safety and efficacy have not been studied in this group.
- Elderly Patients (>65 years): Effectiveness remains consistent with younger adults.
- Renal Impairment: Not studied in patients with kidney dysfunction.
- Hepatic Impairment: Dose adjustment is required for patients with moderate to severe liver impairment.
(Always take medication as per the advice of a registered physician.)
✔️ Drug Interactions
- Studies suggest a low likelihood of drug interactions.
- Lubiprostone is not metabolized by cytochrome P450 enzymes, reducing the risk of interactions with other medications.
- No significant protein-binding interactions have been identified.
✔️ Contraindications
Not to be used in patients with known or suspected mechanical gastrointestinal obstruction.
✔️ Possible Side Effects
- Common: Nausea, vomiting, loose stools, dry mouth, stomach discomfort, dizziness, headache.
✔️ Pregnancy & Lactation
- Pregnancy Category C: Should only be used during pregnancy if the benefits outweigh the potential risks to the fetus.
- Breastfeeding: It is unknown whether the drug is excreted in human milk.
✔️ Precautions & Warnings
- Nausea: May occur; taking the medication with food may help reduce nausea.
- Diarrhea: Should not be used in patients with severe diarrhea.
- Bowel Obstruction: Before starting treatment, ensure there is no mechanical gastrointestinal obstruction if symptoms suggest one.
✔️ Storage Conditions
- Store in a cool, dry place below 25°C.
- Protect from light.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
